Synthesis, characterization, and biological studies of some biometal complexes

Abstract Background Metal complexes Cu[C 13 H 8 O 4 N] 2 2, Ni[C l3 3, and Co[C of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C 9 1 . All are well characterized by various spectral physical methods. The antimicrobial activity has studied against some pathogenic bacteria fungi. Results indicate that higher than free ligand. This would suggest chelation reduces considerably polarity metal ions in which turn increases hydrophobic character chelate thus enables permeation, through lipid layer microorganisms. were assessed for their anticancer studies a panel selected cancer cells HOP62 BT474 respectively. showed promising chemotherapeutic alternatives search agents. fluorescence quenching phenomenon is observed complexes. Conclusion octahedral transition obtained treatment 2-furylglyoxal-anthranilic acetate. Complexes under investigations shown antimicrobial, potential anticancer, DNA binding studies. Graphical abstract